Non-hormonal \u00b7 Vasomotor
Fezolinetant (Veozah): non-hormonal hot flash option
Fezolinetant is an NK3 receptor antagonist that blocks the KNDy neuron pathway driving hot flashes. Effective non-hormonal option for women who can't or won't use estrogen. Requires LFT monitoring.
Key points
- Baseline LFTs
- Repeat monthly x3 then periodically
- Not for hepatic impairment
Frequently asked questions
How effective is fezolinetant?
~60% reduction in moderate-to-severe hot flashes at 12 weeks.
What's the monitoring?
LFTs at baseline, month 1, 2, 3, then periodically.
Cost?
Roughly $550/month without insurance.
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Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-06-19. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.