Hormone therapy — brand

Dotti

Twice-weekly estradiol patch (generic Vivelle-Dot)

Authorized generic of Vivelle-Dot — twice-weekly small matrix estradiol patch.

Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-07-03

What it is

Dotti is an authorized generic of Vivelle-Dot — a small twice-weekly 17β-estradiol matrix patch.

Same strengths: 0.025, 0.0375, 0.05, 0.075, 0.1 mg/day.

How it works

Transdermal estradiol absorbed through the skin into circulation.

Who it's for

Women under 60 or within 10 years of menopause with vasomotor symptoms
Patients who want a smaller, more discreet patch

Who should not take it

Estrogen-sensitive cancer history
Recent clot, stroke, or MI
Active liver disease

Common side effects

Patch-site irritation
Breast tenderness, headache initially
Spotting on combined therapy

Evidence summary

FDA-approved as bioequivalent to Vivelle-Dot for moderate-to-severe vasomotor symptoms.

Brand-name vs compounded

Dotti is an FDA-approved brand-name product. Many Kindr patients use compounded alternatives prepared by a state-licensed 503A pharmacy when a custom dose, custom combination, or different delivery form is clinically preferable. Both pathways are available through Kindr — your provider will recommend based on your individual needs.

Brand-name Dotti

FDA-approved finished product
Standardized doses
Available at most pharmacies
May be covered by insurance
Limited dose options

Compounded alternative

Custom dose for your needs
Prepared by FDA-registered 503A pharmacy
Not FDA-approved as a finished product
Typically cash pay
Flexible delivery forms

FAQ

Is Dotti the same as Vivelle-Dot?

It is an authorized generic — bioequivalent and clinically interchangeable.

Why prescribe Dotti vs Vivelle-Dot?

Cost and insurance coverage are usually the deciding factors.

Sources

Medically reviewed by Kindr Health Clinical Team
Kindr Health Inc. — Editorial & Clinical Team (physician-supervised)
NPI 1609792902 · Last reviewed: July 3, 2026

Other medications

Estradiol →

Hormone therapy

Micronized Progesterone →

Hormone therapy

Testosterone (low-dose, female-physiologic) →

Hormone therapy

Semaglutide →

GLP-1 weight care

This page is educational and is not a substitute for a clinical evaluation. Whether any medication is appropriate for you depends on your full medical history. Kindr providers make individualized prescribing decisions during a clinical visit.