Hormone therapy — brand

Endometrin

Progesterone vaginal insert

Bioidentical progesterone vaginal insert — primarily used in fertility treatment.

Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-07-03

What it is

Endometrin is a brand-name 100 mg bioidentical progesterone vaginal insert.

Primary indication is ART/IVF luteal support.

How it works

Vaginal absorption with high uterine concentration via first uterine pass.

Who it's for

Fertility treatment (primary)
Off-label HRT use in patients intolerant of oral progesterone

Who should not take it

Active liver disease
Active thromboembolic disease
Undiagnosed vaginal bleeding

Common side effects

Vaginal irritation, discharge

Evidence summary

FDA-approved for ART luteal support.

Brand-name vs compounded

Endometrin is an FDA-approved brand-name product. Many Kindr patients use compounded alternatives prepared by a state-licensed 503A pharmacy when a custom dose, custom combination, or different delivery form is clinically preferable. Both pathways are available through Kindr — your provider will recommend based on your individual needs.

Brand-name Endometrin

FDA-approved finished product
Standardized doses
Available at most pharmacies
May be covered by insurance
Limited dose options

Compounded alternative

Custom dose for your needs
Prepared by FDA-registered 503A pharmacy
Not FDA-approved as a finished product
Typically cash pay
Flexible delivery forms

FAQ

Endometrin vs Crinone?

Endometrin is a tablet-style insert; Crinone is a gel. Both deliver progesterone vaginally.

Sources

Medically reviewed by Kindr Health Clinical Team
Kindr Health Inc. — Editorial & Clinical Team (physician-supervised)
NPI 1609792902 · Last reviewed: July 3, 2026

Other medications

Estradiol →

Hormone therapy

Micronized Progesterone →

Hormone therapy

Testosterone (low-dose, female-physiologic) →

Hormone therapy

Semaglutide →

GLP-1 weight care

This page is educational and is not a substitute for a clinical evaluation. Whether any medication is appropriate for you depends on your full medical history. Kindr providers make individualized prescribing decisions during a clinical visit.