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Reference sheet · Endocrine · CPC catalog code CRFS-002
Reference standards in the Endocrine class are typically shipped as lyophilized powder and stored desiccated at −20 °C protected from light. Once reconstituted in bacteriostatic water or the assay-appropriate buffer, aliquot and store at −80 °C to minimize freeze–thaw cycles. Confirm handling requirements against your institutional biosafety and radiation protocols before use.
[DPhe12, Nle21,38, Glu30, Lys33] Corticotropin Releasing Factor (12-41), human, rat sits within the Endocrine research class (CPC reference CRFS-002). Endocrine peptides bind class A/B GPCRs and RTKs on hormone-responsive tissues, triggering canonical cAMP, IP₃/Ca²⁺, and MAPK pathways that regulate secretion, growth, and metabolism. Investigators typically incorporate [DPhe12, Nle21,38, Glu30, Lys33] Corticotropin Releasing Factor (12-41), human, rat as a reference standard, tool ligand, or substrate in the assay contexts listed above. HTRF cAMP, calcium mobilization (FLIPR), and radioligand binding are the standard readouts.
[DPhe12, Nle21,38, Glu30, Lys33] Corticotropin Releasing Factor (12-41), human, rat (CPC catalog code CRFS-002) is a synthetic endocrine research peptide in the endocrine category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.
Published and internal research programs use [DPhe12, Nle21,38, Glu30, Lys33] Corticotropin Releasing Factor (12-41), human, rat as a reference standard in endocrine workflows — for example, receptor-binding and functional selectivity studies and second-messenger (camp / ip₁) profiling. Human clinical evidence is not established.
No. [DPhe12, Nle21,38, Glu30, Lys33] Corticotropin Releasing Factor (12-41), human, rat is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.
In a endocrine workflow, [DPhe12, Nle21,38, Glu30, Lys33] Corticotropin Releasing Factor (12-41), human, rat is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. HTRF cAMP, calcium mobilization (FLIPR), and radioligand binding are the standard readouts.
Other reference standards in the same class — commonly cross-referenced during assay design and comparator selection.