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Reference sheet · Cell-Penetrating · CPC catalog code TAT-004
Reference standards in the Cell-Penetrating class are typically shipped as lyophilized powder and stored desiccated at −20 °C protected from light. Once reconstituted in bacteriostatic water or the assay-appropriate buffer, aliquot and store at −80 °C to minimize freeze–thaw cycles. Confirm handling requirements against your institutional biosafety and radiation protocols before use.
Ala-Leu-Ala-Leu sits within the Cell-Penetrating research class (CPC reference TAT-004). CPPs cross cellular membranes through energy-independent direct translocation and/or endocytic uptake driven by cationic residues (arginine-rich sequences) or amphipathic architecture. They are typically conjugated to a cargo of interest. Investigators typically incorporate Ala-Leu-Ala-Leu as a reference standard, tool ligand, or substrate in the assay contexts listed above. Fluorescent-conjugate flow cytometry and confocal imaging are the standard uptake readouts.
Ala-Leu-Ala-Leu (CPC catalog code TAT-004) is a synthetic cell-penetrating peptide (cpp) in the cell-penetrating category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.
Published and internal research programs use Ala-Leu-Ala-Leu as a reference standard in cell-penetrating workflows — for example, intracellular cargo delivery (peptides, sirna, proteins) and endosomal-escape and trafficking studies. Human clinical evidence is not established.
No. Ala-Leu-Ala-Leu is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.
In a cell-penetrating workflow, Ala-Leu-Ala-Leu is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. Fluorescent-conjugate flow cytometry and confocal imaging are the standard uptake readouts.
Other reference standards in the same class — commonly cross-referenced during assay design and comparator selection.