Ion Channel Toxins · Ion-channel toxin (research reagent) · APAM-001
Apamin
- Drug class
- Ion-channel toxin (research reagent)
- Status
- Research use only
- Catalog code
- APAM-001
- Also known as
- APAM-001
- Reviewed
- 2026-06-01 · Kindr Health Clinical Team
What Apamin is studied for
- Patch-clamp characterization of channel subtypes
- Neuronal excitability and pain-circuit research
- Cardiac electrophysiology and arrhythmia models
- Structure–function mapping of channel pores
Mechanism of action
Apamin sits within the Ion Channel Toxins research class (CPC reference APAM-001). Ion-channel toxins bind with sub-nanomolar affinity to specific channel subtypes (Kv, Nav, Cav, NMDA), stabilizing closed, open, or inactivated states. They are among the most selective tools available for dissecting channel function. Investigators typically incorporate Apamin as a reference standard, tool ligand, or substrate in the assay contexts listed above. Manual or automated patch clamp (QPatch, Patchliner) and radioligand binding are the standard readouts.
Frequently asked questions
What is Apamin?
Apamin (CPC catalog code APAM-001) is a synthetic ion-channel toxin (research reagent) in the ion channel toxins category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.
What is Apamin studied for?
Published and internal research programs use Apamin as a reference standard in ion channel toxins workflows — for example, patch-clamp characterization of channel subtypes and neuronal excitability and pain-circuit research. Human clinical evidence is not established.
Is Apamin FDA-approved for human use?
No. Apamin is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.
How is Apamin typically used in the lab?
In a ion channel toxins workflow, Apamin is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. Manual or automated patch clamp (QPatch, Patchliner) and radioligand binding are the standard readouts.
How should Apamin be stored?
Toxins are extremely potent. Handle with appropriate PPE. Store lyophilized at −20 °C; keep reconstituted stocks in silanized tubes to prevent adsorption. Follow your institution's standard operating procedures for handling synthetic peptides.
Where does the Apamin product page point to?
This kindr reference page mirrors CPC Scientific's catalog metadata for APAM-001. The upstream reference sheet — including sequence, purity, MW, and application notes where published — is linked from the buy panel. All orders placed on kindr Peptides ship internationally under research-use terms only.
What quality specifications apply to Apamin?
Research-grade peptides in the CPC catalog are synthesized by solid-phase peptide synthesis (SPPS), purified by preparative RP-HPLC, and characterized by analytical HPLC and mass spectrometry. Typical purity is ≥95%; certificate of analysis is available on request.
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