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Opioid · Opioid-receptor research peptide · ENKP-005

[DPhe2,5,(pCl)Phe4] Enkephalin

Research use · ships internationally
$85.00 / 1mg vial
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[DPhe2,5,(pCl)Phe4] Enkephalin reference vial
Drug class
Opioid-receptor research peptide
Status
Research use only
Catalog code
ENKP-005
Also known as
ENKP-005
Reviewed
2026-06-01 · Kindr Health Clinical Team

What [DPhe2,5,(pCl)Phe4] Enkephalin is studied for

  • Opioid-receptor binding and selectivity profiling
  • β-arrestin recruitment and biased-agonism studies
  • Analgesic mechanism research
  • Tolerance and dependence models

Mechanism of action

[DPhe2,5,(pCl)Phe4] Enkephalin sits within the Opioid research class (CPC reference ENKP-005). Opioid peptides bind μ, δ, and κ receptors — Gi/o-coupled GPCRs that inhibit adenylate cyclase, activate GIRK channels, and modulate calcium currents to produce analgesia, tolerance, and reward-circuit effects. Investigators typically incorporate [DPhe2,5,(pCl)Phe4] Enkephalin as a reference standard, tool ligand, or substrate in the assay contexts listed above. GTPγS binding, cAMP HTRF, and β-arrestin PathHunter assays.

Frequently asked questions

What is [DPhe2,5,(pCl)Phe4] Enkephalin?

[DPhe2,5,(pCl)Phe4] Enkephalin (CPC catalog code ENKP-005) is a synthetic opioid-receptor research peptide in the opioid category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.

What is [DPhe2,5,(pCl)Phe4] Enkephalin studied for?

Published and internal research programs use [DPhe2,5,(pCl)Phe4] Enkephalin as a reference standard in opioid workflows — for example, opioid-receptor binding and selectivity profiling and β-arrestin recruitment and biased-agonism studies. Human clinical evidence is not established.

Is [DPhe2,5,(pCl)Phe4] Enkephalin FDA-approved for human use?

No. [DPhe2,5,(pCl)Phe4] Enkephalin is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.

How is [DPhe2,5,(pCl)Phe4] Enkephalin typically used in the lab?

In a opioid workflow, [DPhe2,5,(pCl)Phe4] Enkephalin is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. GTPγS binding, cAMP HTRF, and β-arrestin PathHunter assays.

How should [DPhe2,5,(pCl)Phe4] Enkephalin be stored?

Store lyophilized at −20 °C. Handle as Schedule research reagents where applicable. Follow your institution's standard operating procedures for handling synthetic peptides.

Where does the [DPhe2,5,(pCl)Phe4] Enkephalin product page point to?

This kindr reference page mirrors CPC Scientific's catalog metadata for ENKP-005. The upstream reference sheet — including sequence, purity, MW, and application notes where published — is linked from the buy panel. All orders placed on kindr Peptides ship internationally under research-use terms only.

What quality specifications apply to [DPhe2,5,(pCl)Phe4] Enkephalin?

Research-grade peptides in the CPC catalog are synthesized by solid-phase peptide synthesis (SPPS), purified by preparative RP-HPLC, and characterized by analytical HPLC and mass spectrometry. Typical purity is ≥95%; certificate of analysis is available on request.

Internal reference sheetOpen the [DPhe2,5,(pCl)Phe4] Enkephalin physicochemical & handling reference →Upstream reference sheetView CPC Scientific catalog page for ENKP-005 →Add to cart · International research catalogBuy [DPhe2,5,(pCl)Phe4] Enkephalin in the kindr Peptides Shop →

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Research & medical disclosure. This page is educational reference content reviewed by a licensed physician. It is not medical advice and does not establish a clinician–patient relationship. Peptides offered on the kindr Peptides Shop are sold for in vitro laboratory research purposes only and ship internationally — not to the United States. For U.S. clinical care, use the kindr Longevity intake.