Opioid · Opioid-receptor research peptide · OPIO-011
Nociceptin (1-13) amide
- Drug class
- Opioid-receptor research peptide
- Status
- Research use only
- Catalog code
- OPIO-011
- Also known as
- OPIO-011
- Reviewed
- 2026-06-01 · Kindr Health Clinical Team
What Nociceptin (1-13) amide is studied for
- Opioid-receptor binding and selectivity profiling
- β-arrestin recruitment and biased-agonism studies
- Analgesic mechanism research
- Tolerance and dependence models
Mechanism of action
Nociceptin (1-13) amide sits within the Opioid research class (CPC reference OPIO-011). Opioid peptides bind μ, δ, and κ receptors — Gi/o-coupled GPCRs that inhibit adenylate cyclase, activate GIRK channels, and modulate calcium currents to produce analgesia, tolerance, and reward-circuit effects. Investigators typically incorporate Nociceptin (1-13) amide as a reference standard, tool ligand, or substrate in the assay contexts listed above. GTPγS binding, cAMP HTRF, and β-arrestin PathHunter assays.
Frequently asked questions
What is Nociceptin (1-13) amide?
Nociceptin (1-13) amide (CPC catalog code OPIO-011) is a synthetic opioid-receptor research peptide in the opioid category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.
What is Nociceptin (1-13) amide studied for?
Published and internal research programs use Nociceptin (1-13) amide as a reference standard in opioid workflows — for example, opioid-receptor binding and selectivity profiling and β-arrestin recruitment and biased-agonism studies. Human clinical evidence is not established.
Is Nociceptin (1-13) amide FDA-approved for human use?
No. Nociceptin (1-13) amide is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.
How is Nociceptin (1-13) amide typically used in the lab?
In a opioid workflow, Nociceptin (1-13) amide is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. GTPγS binding, cAMP HTRF, and β-arrestin PathHunter assays.
How should Nociceptin (1-13) amide be stored?
Store lyophilized at −20 °C. Handle as Schedule research reagents where applicable. Follow your institution's standard operating procedures for handling synthetic peptides.
Where does the Nociceptin (1-13) amide product page point to?
This kindr reference page mirrors CPC Scientific's catalog metadata for OPIO-011. The upstream reference sheet — including sequence, purity, MW, and application notes where published — is linked from the buy panel. All orders placed on kindr Peptides ship internationally under research-use terms only.
What quality specifications apply to Nociceptin (1-13) amide?
Research-grade peptides in the CPC catalog are synthesized by solid-phase peptide synthesis (SPPS), purified by preparative RP-HPLC, and characterized by analytical HPLC and mass spectrometry. Typical purity is ≥95%; certificate of analysis is available on request.
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