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Cell-Penetrating · Cell-penetrating peptide (CPP) · TAT-004

Ala-Leu-Ala-Leu

Research use · ships internationally
$95.00 / 1mg vial
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Ala-Leu-Ala-Leu reference vial
Drug class
Cell-penetrating peptide (CPP)
Status
Research use only
Catalog code
TAT-004
Also known as
TAT-004
Reviewed
2026-06-01 · Kindr Health Clinical Team

What Ala-Leu-Ala-Leu is studied for

  • Intracellular cargo delivery (peptides, siRNA, proteins)
  • Endosomal-escape and trafficking studies
  • In vitro screens of CPP variants for uptake efficiency
  • Structure–activity work on cationic / amphipathic CPPs

Mechanism of action

Ala-Leu-Ala-Leu sits within the Cell-Penetrating research class (CPC reference TAT-004). CPPs cross cellular membranes through energy-independent direct translocation and/or endocytic uptake driven by cationic residues (arginine-rich sequences) or amphipathic architecture. They are typically conjugated to a cargo of interest. Investigators typically incorporate Ala-Leu-Ala-Leu as a reference standard, tool ligand, or substrate in the assay contexts listed above. Fluorescent-conjugate flow cytometry and confocal imaging are the standard uptake readouts.

Frequently asked questions

What is Ala-Leu-Ala-Leu?

Ala-Leu-Ala-Leu (CPC catalog code TAT-004) is a synthetic cell-penetrating peptide (cpp) in the cell-penetrating category. It is provided as a lyophilized ~1 mg vial for in-vitro research use only.

What is Ala-Leu-Ala-Leu studied for?

Published and internal research programs use Ala-Leu-Ala-Leu as a reference standard in cell-penetrating workflows — for example, intracellular cargo delivery (peptides, sirna, proteins) and endosomal-escape and trafficking studies. Human clinical evidence is not established.

Is Ala-Leu-Ala-Leu FDA-approved for human use?

No. Ala-Leu-Ala-Leu is a research-grade reference peptide and is not approved by the FDA or any national regulator for human or veterinary therapeutic use. It is offered exclusively for in-vitro laboratory research and does not ship to the United States for consumer use.

How is Ala-Leu-Ala-Leu typically used in the lab?

In a cell-penetrating workflow, Ala-Leu-Ala-Leu is reconstituted in sterile buffer or DMSO (solubility-dependent) and applied in the researcher's chosen assay format. Fluorescent-conjugate flow cytometry and confocal imaging are the standard uptake readouts.

How should Ala-Leu-Ala-Leu be stored?

Store lyophilized at −20 °C. Aliquot reconstituted stocks to avoid freeze–thaw damage. Follow your institution's standard operating procedures for handling synthetic peptides.

Where does the Ala-Leu-Ala-Leu product page point to?

This kindr reference page mirrors CPC Scientific's catalog metadata for TAT-004. The upstream reference sheet — including sequence, purity, MW, and application notes where published — is linked from the buy panel. All orders placed on kindr Peptides ship internationally under research-use terms only.

What quality specifications apply to Ala-Leu-Ala-Leu?

Research-grade peptides in the CPC catalog are synthesized by solid-phase peptide synthesis (SPPS), purified by preparative RP-HPLC, and characterized by analytical HPLC and mass spectrometry. Typical purity is ≥95%; certificate of analysis is available on request.

Internal reference sheetOpen the Ala-Leu-Ala-Leu physicochemical & handling reference →Upstream reference sheetView CPC Scientific catalog page for TAT-004 →Add to cart · International research catalogBuy Ala-Leu-Ala-Leu in the kindr Peptides Shop →

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Research & medical disclosure. This page is educational reference content reviewed by a licensed physician. It is not medical advice and does not establish a clinician–patient relationship. Peptides offered on the kindr Peptides Shop are sold for in vitro laboratory research purposes only and ship internationally — not to the United States. For U.S. clinical care, use the kindr Longevity intake.