Longevity · Khavinson tetrapeptide (research)
Epithalon
- Drug class
- Khavinson tetrapeptide (research)
- Status
- Compounded (503A)
- Also known as
- Epitalon, AEDG peptide, Epithalamin analog
- Reviewed
- 2026-06-01 · Kindr Health Clinical Team
What Epithalon is studied for
- Telomerase activation (in vitro and animal)
- Pineal-axis and melatonin rhythm support
- Longevity and age-related biomarker research
Mechanism of action
Activates telomerase in somatic cells, lengthening telomeres in cell culture. In vivo, it restores pineal-axis melatonin rhythm and modulates expression of genes linked to circadian regulation and DNA repair.
Frequently asked questions
What does the research show?
Most evidence is from Khavinson-lab studies in rodents and small Russian cohorts — showing extended median lifespan, restored melatonin rhythm, and improved age-related biomarkers. Independent replication is limited.
How is it dosed?
Typical research protocol: 5–10 mg subcutaneously daily for 10–20 days, 1–2 cycles per year. No validated clinical dose exists.
Is it safe?
Short-term human tolerability in published Russian studies appears good. Long-term safety, particularly any theoretical cancer-risk from telomerase activation, is not well characterized.
Build the Epithalon protocol stack
Research protocols commonly pair Epithalon with the peptides below. Add all three vials to unlock the bundle discount at checkout.
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