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Longevity · Khavinson tetrapeptide (research)

Epithalon

Epithalon reference image
Drug class
Khavinson tetrapeptide (research)
Status
Compounded (503A)
Also known as
Epitalon, AEDG peptide, Epithalamin analog
Reviewed
2026-06-01 · Dr. Ana Lisa Carr, MD

What Epithalon is studied for

  • Telomerase activation (in vitro and animal)
  • Pineal-axis and melatonin rhythm support
  • Longevity and age-related biomarker research

Mechanism of action

Activates telomerase in somatic cells, lengthening telomeres in cell culture. In vivo, it restores pineal-axis melatonin rhythm and modulates expression of genes linked to circadian regulation and DNA repair.

Frequently asked questions

What does the research show?

Most evidence is from Khavinson-lab studies in rodents and small Russian cohorts — showing extended median lifespan, restored melatonin rhythm, and improved age-related biomarkers. Independent replication is limited.

How is it dosed?

Typical research protocol: 5–10 mg subcutaneously daily for 10–20 days, 1–2 cycles per year. No validated clinical dose exists.

Is it safe?

Short-term human tolerability in published Russian studies appears good. Long-term safety, particularly any theoretical cancer-risk from telomerase activation, is not well characterized.

International research catalogView Epithalon in the kindr Peptides Shop →

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Research & medical disclosure. This page is educational reference content reviewed by a licensed physician. It is not medical advice and does not establish a clinician–patient relationship. Peptides offered on the kindr Peptides Shop are sold for in vitro laboratory research purposes only and ship internationally — not to the United States. For U.S. clinical care, use the kindr Longevity intake.