Skin & Hair · Copper-binding tripeptide (cosmetic / research)
GHK-Cu
- Drug class
- Copper-binding tripeptide (cosmetic / research)
- Status
- Compounded (503A)
- Also known as
- Copper peptide, Cu-GHK, Glycyl-L-histidyl-L-lysine copper
- Reviewed
- 2026-06-01 · Dr. Ana Lisa Carr, MD
What GHK-Cu is studied for
- Collagen and elastin synthesis (skin remodeling)
- Hair follicle anagen-phase support
- Wound healing and tissue repair
- Antioxidant and anti-inflammatory activity
Mechanism of action
GHK forms a high-affinity complex with copper(II). The copper complex modulates expression of ~4,000 human genes — broadly upregulating collagen, elastin, and antioxidant pathways while downregulating inflammatory and senescence markers.
Frequently asked questions
What does GHK-Cu do for skin?
Increases collagen and elastin production, improves dermal thickness and elasticity, reduces fine lines, and accelerates wound healing in published trials.
Does it work for hair loss?
Preliminary evidence shows extended anagen (growth) phase and increased follicle size. Often combined with minoxidil or finasteride in scalp formulations.
How is it applied?
Topical serums (most common cosmetic use, 1–3% concentration), microneedling solutions, and compounded subcutaneous or scalp injections in research settings.
Is it safe?
Topical use is well tolerated. Injectable use is research-stage; theoretical concerns include excess copper exposure with overuse.