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Growth Hormone Axis · Selective GH secretagogue (ghrelin agonist)

Ipamorelin

Ipamorelin reference image
Drug class
Selective GH secretagogue (ghrelin agonist)
Status
Compounded (503A)
Reviewed
2026-06-01 · Dr. Ana Lisa Carr, MD

What Ipamorelin is studied for

  • Growth-hormone axis support (off-label)
  • Sleep quality and slow-wave sleep
  • Body composition and recovery

Mechanism of action

Binds the growth hormone secretagogue receptor (GHSR, the ghrelin receptor) on pituitary somatotrophs. Selective signaling triggers GH release without activating the cortisol or prolactin pathways.

Frequently asked questions

Why combine ipamorelin with CJC-1295?

CJC raises GHRH-receptor stimulation (amplitude); ipamorelin triggers the pulse via the ghrelin receptor (frequency). The two together produce a larger, cleaner GH pulse than either alone.

Does ipamorelin raise cortisol?

No — that is its main advantage over GHRP-2 and GHRP-6. In trials, cortisol and prolactin remain at baseline.

How is it dosed?

Typical research dose is 100–300 mcg subcutaneously, 1–3x daily. Most protocols include a bedtime dose to align with the natural GH pulse.

International research catalogView Ipamorelin in the kindr Peptides Shop →

Related peptides in Growth Hormone Axis

SermorelinA gentler way to support your natural GH rhythm.CJC-1295 + IpamorelinCombination protocol for sleep, recovery, and body composition.TesamorelinGHRH analog studied for visceral fat reduction and body composition.CJC-1295 (No DAC)Short-acting GHRH analog — clean pulsatile GH release.CJC-1295 with DACLong-acting GHRH analog with drug affinity complex for sustained GH support.HGH 191AARecombinant human growth hormone (somatropin) — 191 amino acid sequence.
Research & medical disclosure. This page is educational reference content reviewed by a licensed physician. It is not medical advice and does not establish a clinician–patient relationship. Peptides offered on the kindr Peptides Shop are sold for in vitro laboratory research purposes only and ship internationally — not to the United States. For U.S. clinical care, use the kindr Longevity intake.