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Metabolic · GLP-1 / GIP / glucagon triple agonist (investigational)

Retatrutide

Research use · ships internationally
$125.00 / 10mg vial
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Retatrutide reference vial
Drug class
GLP-1 / GIP / glucagon triple agonist (investigational)
Status
Compounded (503A)
Also known as
LY3437943, reta
Reviewed
2026-06-01 · Kindr Health Clinical Team

What Retatrutide is studied for

  • Investigational chronic weight management
  • Type 2 diabetes (phase 2/3)
  • Hepatic steatosis (MASLD) reduction
  • Cardiometabolic phenotype research

Mechanism of action

Triple agonist of GLP-1, GIP, and glucagon receptors. The glucagon arm increases energy expenditure and may explain the larger weight-loss signal vs. tirzepatide and semaglutide.

Frequently asked questions

Is retatrutide FDA-approved?

No. As of mid-2026 retatrutide is in phase 3 trials (TRIUMPH program) for obesity and type 2 diabetes. Expected FDA decision is 2026–2027.

How much weight do people lose on retatrutide?

In the phase 2 obesity trial, average weight loss at 48 weeks was 8.7% (1 mg), 17.1% (4 mg), 22.8% (8 mg), and 24.2% (12 mg) — without a clear plateau, suggesting more loss with longer dosing.

How is it different from tirzepatide?

Retatrutide adds glucagon-receptor activation, which raises energy expenditure (basal metabolic rate). Tirzepatide is GLP-1 + GIP only. Side-effect profile is similar but heart-rate elevation is more notable with retatrutide.

What are the side effects?

GI effects (nausea, diarrhea, vomiting) similar to other incretins, plus a small dose-dependent heart-rate increase (~3–6 bpm). Long-term cardiovascular safety is still being studied.

Clinical guideRead the full Retatrutide clinical guide →Add to cart · International research catalogBuy Retatrutide in the kindr Peptides Shop →
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Build the Retatrutide protocol stack

Research protocols commonly pair Retatrutide with the peptides below. Add all three vials to unlock the bundle discount at checkout.

This peptide
Retatrutide
$125.00
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Cagrilintide
Long-acting amylin analog — often paired with semaglutide (CagriSema).
$110.00
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AOD-9604
hGH fragment targeting fat metabolism without affecting IGF-1.
$50.00
$285.00 $242.25
You save $42.75 on the stack
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Related peptides in Metabolic

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SemaglutideGLP-1 for weight, appetite, and metabolic health.
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TirzepatideDual GLP-1 / GIP for next-generation metabolic care.
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CagrilintideLong-acting amylin analog — often paired with semaglutide (CagriSema).
View details
SLU-PP-332ERR agonist studied as an exercise mimetic for endurance and metabolism.
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AOD-9604hGH fragment targeting fat metabolism without affecting IGF-1.
View details

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Research & medical disclosure. This page is educational reference content reviewed by a licensed physician. It is not medical advice and does not establish a clinician–patient relationship. Peptides offered on the kindr Peptides Shop are sold for in vitro laboratory research purposes only and ship worldwide, including the United States. For U.S. clinical care, use the kindr Longevity intake.