Knowledge Graph · Condition
Cardiovascular Disease
A class of diseases involving the heart or blood vessels.
Authoritative sources
Evidence base
Randomized Controlled Trial · 2016 · Landmark
Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol
New England Journal of Medicine · Hodis HN, Mack WJ, Henderson VW, et al. (ELITE Trial)
This trial provided direct evidence for the "timing hypothesis": starting HRT early in menopause protects arteries, while starting it late does not.
Randomized Controlled Trial · 2002 · Landmark
Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women
JAMA · Rossouw JE, Anderson GL, Prentice RL, et al. (Writing Group for the Women's Health Initiative)
The Women's Health Initiative was the landmark trial that reshaped how doctors prescribe hormone therapy after menopause. Later re-analyses showed the risk profile is very different for women who start HRT closer to menopause.
Where Cardiovascular Disease appears on Kindr Health
Guide
- Menopause Cardiovascular Longevityprimary topic
Data hub
This page is part of Kindr Health's public Knowledge Graph. Content is for educational purposes only and is not medical advice.