Estradiol

Authoritative sources

• Wikidata (Q409712)
• MeSH (D004958)
• Wikipedia

Evidence base

• Randomized Controlled Trial · 2016 · Landmark

  Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol

  New England Journal of Medicine · Hodis HN, Mack WJ, Henderson VW, et al. (ELITE Trial)

  This trial provided direct evidence for the "timing hypothesis": starting HRT early in menopause protects arteries, while starting it late does not.

• Randomized Controlled Trial · 2015 · Landmark

  Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women

  PLoS Medicine · Gleason CE, Dowling NM, Wharton W, et al. (KEEPS Cognitive and Affective Study)

  When hormone therapy is started early in menopause, it does not appear to harm memory or thinking, and may improve mood.

• Systematic Review · 2024

  Non-genetic factors and breast cancer: an umbrella review of meta-analyses

  BMC cancer · Yiallourou A, Pantavou K, Markozannes G, Pilavas A, et al.

• Systematic Review · 2023

  Menstrual Cycle and Sport Injuries: A Systematic Review

  International journal of environmental research and public health · Martínez-Fortuny N, Alonso-Calvete A, Da Cuña-Carrera I, Abalo-Núñez R

• Meta-Analysis · 2023

  Clomiphene citrate for male infertility: A systematic review and meta-analysis

  Andrology · Huijben M, Huijsmans RLN, Lock MTWT, de Kemp VF, et al.

• Meta-Analysis · 2022

  Soy Isoflavones and Breast Cancer Risk: A Meta-analysis

  In vivo (Athens, Greece) · Boutas I, Kontogeorgi A, Dimitrakakis C, Kalantaridou SN

• Meta-Analysis · 2022

  Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis

  Andrology · Huijben M, Lock MTWT, de Kemp VF, de Kort LMO, et al.

• Meta-Analysis · 2022

  Systematic Review and Meta-analysis: Changes of Gut Microbiota before and after Menopause

  Disease markers · Yang M, Wen S, Zhang J, Peng J, et al.

• Meta-Analysis · 2021

  Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies

  Reproductive toxicology (Elmsford, N.Y.) · Reed KE, Camargo J, Hamilton-Reeves J, Kurzer M, et al.

• Randomized Controlled Trial · 2021

  Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy

  The New England journal of medicine · Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, et al.

Where Estradiol appears on Kindr Health