Knowledge Graph · Hormone
Estradiol
The primary estrogen in humans, responsible for reproductive and sexual functioning.
Authoritative sources
Evidence base
Randomized Controlled Trial · 2016 · Landmark
Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol
New England Journal of Medicine · Hodis HN, Mack WJ, Henderson VW, et al. (ELITE Trial)
This trial provided direct evidence for the "timing hypothesis": starting HRT early in menopause protects arteries, while starting it late does not.
Randomized Controlled Trial · 2015 · Landmark
Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women
PLoS Medicine · Gleason CE, Dowling NM, Wharton W, et al. (KEEPS Cognitive and Affective Study)
When hormone therapy is started early in menopause, it does not appear to harm memory or thinking, and may improve mood.
Where Estradiol appears on Kindr Health
Data hub
Wiki
This page is part of Kindr Health's public Knowledge Graph. Content is for educational purposes only and is not medical advice.