What is hypogonadism?

Hypogonadism is a condition where the body produces insufficient sex hormones, such as testosterone in men or estrogen in women. This deficiency happens because the gonads (testes in men, ovaries in women) are not functioning properly.

What are the symptoms of hypogonadism?

Symptoms of hypogonadism can vary depending on sex and age of onset. In men, symptoms may include reduced libido, erectile dysfunction, fatigue, and loss of muscle mass. In women, symptoms might include irregular or absent menstrual periods, hot flashes, and low libido.

What causes hypogonadism?

Hypogonadism can be caused by problems with the gonads themselves (primary hypogonadism) or by issues with the brain's control over hormone production (secondary hypogonadism). Causes can include genetic conditions, autoimmune disorders, infections, injuries, or certain medical treatments.

How is hypogonadism diagnosed?

Diagnosing hypogonadism typically involves a physical examination, a review of symptoms, and blood tests to measure hormone levels, particularly testosterone or estrogen. Your doctor may also perform additional tests to determine the underlying cause.

What are common treatments for hypogonadism?

Treatment for hypogonadism often involves hormone replacement therapy to restore hormone levels to a normal range. The specific treatment approach depends on the cause, the patient's sex, and their individual health needs.

Knowledge Graph · Condition

Hypogonadism

Diminished functional activity of the gonads leading to low sex hormones.

Authoritative sources

Evidence base

Systematic Review · 2026
Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health
Human reproduction update · Carlomagno F, Tenuta M, Sansone A, Rastrelli G, et al.
Systematic Review · 2025
Comprehensive genotype-phenotype analysis in POLR3-related disorders
HGG advances · Michell-Robinson MA, Perrier S, Gauthier S, Derksen A, et al.
Meta-Analysis · 2024
Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis
European journal of endocrinology · Alexander EC, Faruqi D, Farquhar R, Unadkat A, et al.
Randomized Controlled Trial · 2024
Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism
The Journal of clinical endocrinology and metabolism · Pencina KM, Travison TG, Cunningham GR, Lincoff AM, et al.
Meta-Analysis · 2024
The effects and safety of testosterone replacement therapy for men with hypogonadism: the TestES evidence synthesis and economic evaluation
Health technology assessment (Winchester, England) · Cruickshank M, Hudson J, Hernández R, Aceves-Martins M, et al.
Systematic Review · 2024
Do "testosterone boosters" really increase serum total testosterone? A systematic review
International journal of impotence research · Morgado A, Tsampoukas G, Sokolakis I, Schoentgen N, et al.
Randomized Controlled Trial · 2024
Testosterone Treatment and Fractures in Men with Hypogonadism
The New England journal of medicine · Snyder PJ, Bauer DC, Ellenberg SS, Cauley JA, et al.
Randomized Controlled Trial · 2024
Depressive Syndromes in Men With Hypogonadism in the TRAVERSE Trial: Response to Testosterone-Replacement Therapy
The Journal of clinical endocrinology and metabolism · Bhasin S, Seidman S, Travison TG, Pencina KM, et al.
Systematic Review · 2023
Impact of anabolic androgenic steroids on male sexual and reproductive function: a systematic review
Panminerva medica · Esposito M, Salerno M, Calvano G, Agliozzo R, et al.
Randomized Controlled Trial · 2023
Cardiovascular Safety of Testosterone-Replacement Therapy
The New England journal of medicine · Lincoff AM, Bhasin S, Flevaris P, Mitchell LM, et al.
Systematic Review · 2022
Testosterone Therapy With Subcutaneous Injections: A Safe, Practical, and Reasonable Option
The Journal of clinical endocrinology and metabolism · Figueiredo MG, Gagliano-Jucá T, Basaria S
Meta-Analysis · 2022
Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis
Andrology · Huijben M, Lock MTWT, de Kemp VF, de Kort LMO, et al.
Systematic Review · 2022
Pharmacological treatment strategies for antipsychotic-induced hyperprolactinemia: a systematic review and network meta-analysis
Translational psychiatry · Lu Z, Sun Y, Zhang Y, Chen Y, et al.
Systematic Review · 2021
European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction
European urology · Salonia A, Bettocchi C, Boeri L, Capogrosso P, et al.
Meta-Analysis · 2021
Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis
JAMA network open · Mykoniatis I, Pyrgidis N, Sokolakis I, Ouranidis A, et al.

Where Hypogonadism appears on Kindr Health

Journal

Testosterone For Women In Perimenopause

This page is part of Kindr Health's public Knowledge Graph. Content is for educational purposes only and is not medical advice.