Metformin

Authoritative sources

• Wikidata (Q422129)
• MeSH (D008687)
• Wikipedia

Evidence base

• Meta-Analysis · 2026

  Effects of metformin on head and neck cancer: an umbrella review

  BMC cancer · Mehta V, Fraile JF, Mathur A, Bhadania M, et al.

• Randomized Controlled Trial · 2025

  Efficacy and safety of tirzepatide in children and adolescents with type 2 diabetes (SURPASS-PEDS): a randomised, double-blind, placebo-controlled, phase 3 trial

  Lancet (London, England) · Hannon TS, Chao LC, Barrientos-Pérez M, Pamidipati KC, et al.

• Meta-Analysis · 2025

  The Optimal Dosage and Duration of Metformin for Prevention and Treatment of Antipsychotic-Induced Weight Gain: An Updated Systematic Review and Meta-Analysis

  Schizophrenia bulletin · Peng TR, Chen JA, Lee JA, Hsing CP, et al.

• Randomized Controlled Trial · 2025

  Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: A Randomized Clinical Trial

  JAMA · Pan F, Wang Y, Lim YZ, Urquhart DM, et al.

• Meta-Analysis · 2024

  Metformin and Combined Oral Contraceptive Pills in the Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis

  The Journal of clinical endocrinology and metabolism · Melin J, Forslund M, Alesi S, Piltonen T, et al.

• Systematic Review · 2024

  Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: a systematic review and network meta-analysis

  Reproductive health · Juhász AE, Stubnya MP, Teutsch B, Gede N, et al.

• Systematic Review · 2024

  Bibliometric analysis of metformin as an immunomodulator (2013-2024)

  Frontiers in immunology · Zhou T, Yu Y, Li L, Liu X, et al.

• Randomized Controlled Trial · 2024

  Efficacy and Safety of Metformin and Atorvastatin Combination Therapy vs. Monotherapy with Either Drug in Type 2 Diabetes Mellitus and Dyslipidemia Patients (ATOMIC): Double-Blinded Randomized Controlled Trial

  Diabetes & metabolism journal · Lee JE, Yu SH, Kim SR, Ahn KJ, et al.

• Meta-Analysis · 2024

  Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines

  The Journal of clinical endocrinology and metabolism · Fitz V, Graca S, Mahalingaiah S, Liu J, et al.

• Systematic Review · 2023

  Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review

  Pharmacology · Mueller L, Moser M, Prazak J, Fuster DG, et al.

• Randomized Controlled Trial · 2023

  Fixed-Dose Combination of Dapagliflozin + Sitagliptin + Metformin in Patients with Type 2 Diabetes Poorly Controlled with Metformin: Phase 3, Randomized Comparison with Dual Combinations

  Advances in therapy · Sahay RK, Giri R, Shembalkar JV, Gupta SK, et al.

• Meta-Analysis · 2023

  Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

  Reproductive biology and endocrinology : RB&E · Greff D, Juhász AE, Váncsa S, Váradi A, et al.

• Meta-Analysis · 2022

  Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials

  Frontiers in endocrinology · Nabrdalik K, Skonieczna-Żydecka K, Irlik K, Hendel M, et al.

• Randomized Controlled Trial · 2022

  Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial

  JAMA · Dahl D, Onishi Y, Norwood P, Huh R, et al.

• Meta-Analysis · 2022

  Metformin: Is it a drug for all reasons and diseases?

  Metabolism: clinical and experimental · Triggle CR, Mohammed I, Bshesh K, Marei I, et al.

• Systematic Review · 2021

  Efficacy and Safety of Metformin for Obesity: A Systematic Review

  Pediatrics · Masarwa R, Brunetti VC, Aloe S, Henderson M, et al.

• Systematic Review · 2021

  Metformin and heart failure-related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials

  Heart failure reviews · Dludla PV, Nyambuya TM, Johnson R, Silvestri S, et al.

• Journal Article · 2021

  Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis

  Reproductive health · Zhao H, Xing C, Zhang J, He B

• Randomized Controlled Trial · 2021

  Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial

  Lancet (London, England) · Ludvik B, Giorgino F, Jódar E, Frias JP, et al.

Where Metformin appears on Kindr Health