Knowledge Graph · Condition

Osteoporosis

A bone disease that occurs when bone mineral density and bone mass decrease.

Authoritative sources

Randomized Controlled Trial · 2004 · Landmark
Effects of Conjugated Equine Estrogen in Postmenopausal Women with Hysterectomy
JAMA · Anderson GL, Limacher M, Assaf AR, et al.
For women without a uterus, estrogen-only therapy showed a much more favorable risk profile than the combined therapy arm.
Randomized Controlled Trial · 2002 · Landmark
Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women
JAMA · Rossouw JE, Anderson GL, Prentice RL, et al. (Writing Group for the Women's Health Initiative)
The Women's Health Initiative was the landmark trial that reshaped how doctors prescribe hormone therapy after menopause. Later re-analyses showed the risk profile is very different for women who start HRT closer to menopause.

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