Do I need progesterone if I have Mirena?
Mirena releases levonorgestrel locally.
Duration of protection
Mirena provides HRT-adequate endometrial protection for 5 years.
Off-label use
Endometrial protection on HRT is FDA-approved for Mirena in EU, off-label in US.
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Related: FDA peptide review July 2026 briefing · Peptide therapy hub · Longevity service
Written and medically reviewed by the Kindr Health Clinical Team · Published 2026-06-19 · Last reviewed 2026-07-01. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.