Estrogen

Authoritative sources

• Wikidata (Q132621)
• MeSH (D004967)
• Wikipedia

Evidence base

• Observational Cohort Study · 2023 · Landmark

  Menopausal Hormone Therapy and Risk of Dementia

  BMJ · Pourhadi N, Mørch LS, Holm EA, et al.

  A large Danish study suggested a small association between long-term HRT and dementia risk, but experts caution the study cannot prove HRT causes dementia and contradicts other evidence.

• Systematic Review · 2022 · Landmark

  Menopause and Adhesive Capsulitis of the Shoulder: A Systematic Review

  Journal of Shoulder and Elbow Surgery · Kingston K, Curry EJ, Galvin JW, Li X.

  A systematic review linking estrogen loss during menopause to a higher rate of frozen shoulder, and cautiously suggesting HRT may help.

• Randomized Controlled Trial · 2015 · Landmark

  Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women

  PLoS Medicine · Gleason CE, Dowling NM, Wharton W, et al. (KEEPS Cognitive and Affective Study)

  When hormone therapy is started early in menopause, it does not appear to harm memory or thinking, and may improve mood.

• Randomized Controlled Trial · 2004 · Landmark

  Effects of Conjugated Equine Estrogen in Postmenopausal Women with Hysterectomy

  JAMA · Anderson GL, Limacher M, Assaf AR, et al.

  For women without a uterus, estrogen-only therapy showed a much more favorable risk profile than the combined therapy arm.

• Randomized Controlled Trial · 2002 · Landmark

  Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women

  JAMA · Rossouw JE, Anderson GL, Prentice RL, et al. (Writing Group for the Women's Health Initiative)

  The Women's Health Initiative was the landmark trial that reshaped how doctors prescribe hormone therapy after menopause. Later re-analyses showed the risk profile is very different for women who start HRT closer to menopause.

Where Estrogen appears on Kindr Health