HRT · Combined oral therapy
Fyavolv (ethinyl estradiol / norethindrone acetate): uses, doses, side effects.
Fyavolv is a low-dose continuous-combined menopause pill — one of only a few FDA-approved options that packages estrogen and progestin in a single daily tablet. Here is the clinician-reviewed guide.
What Fyavolv is
Fyavolv is a once-daily oral tablet containing:
- Ethinyl estradiol 2.5 mcg + norethindrone acetate 0.5 mg, or
- Ethinyl estradiol 5 mcg + norethindrone acetate 1 mg.
It is a continuous-combined regimen — the same pill every day, no hormone-free interval — and is prescribed for postmenopausal women who still have a uterus. Fyavolv is the successor brand to Femhrt and Jinteli.
FDA-approved uses
- Treatment of moderate-to-severe vasomotor symptoms (hot flashes, night sweats) associated with menopause.
- Prevention of postmenopausal osteoporosis in women at significant risk, when non-estrogen medications are not appropriate.
How it works
Ethinyl estradiol restores circulating estrogen, calming the thermoregulatory instability that drives hot flashes and preserving bone density. Norethindrone acetate protects the uterine lining from unopposed estrogen stimulation, preventing endometrial hyperplasia and cancer.
Who Fyavolv is best for
- Postmenopausal women with a uterus and moderate-to-severe hot flashes.
- Women who prefer a single once-daily pill over separate estrogen and progesterone prescriptions.
- Women without contraindications to oral estrogen (VTE history, migraine with aura, high triglycerides, gallbladder disease, active liver disease, unexplained vaginal bleeding, breast cancer history).
How Fyavolv compares to other combined HRT pills
- Fyavolv vs Activella — Activella uses bioidentical 17β-estradiol; Fyavolv uses ethinyl estradiol (more potent, slightly higher clot risk). Activella is more commonly first-line in modern practice.
- Fyavolv vs Prempro — Prempro uses conjugated equine estrogens and medroxyprogesterone; Fyavolv is a lower-dose ethinyl estradiol / norethindrone combination.
- Fyavolv vs transdermal (CombiPatch, Climara Pro) — patches bypass the liver and carry lower VTE risk. Preferred for women at elevated clot or triglyceride risk.
Prescribing Fyavolv through Kindr
Complete a menopause intake and a board-certified clinician licensed in your state will review within one business day. If Fyavolv (or a better-suited alternative) is appropriate, it ships from a licensed U.S. pharmacy. Available in all 50 states.
Frequently asked questions
What is Fyavolv?
Fyavolv is a low-dose combined hormone replacement pill containing ethinyl estradiol 2.5 mcg (or 5 mcg) plus norethindrone acetate 0.5 mg (or 1 mg). It is FDA-approved to treat moderate-to-severe hot flashes and night sweats and to prevent postmenopausal osteoporosis in women with a uterus.
Is Fyavolv the same as Femhrt or Jinteli?
Yes — Fyavolv is the current U.S. brand name for the same low-dose ethinyl estradiol / norethindrone acetate combination previously sold as Femhrt and Jinteli. The formulation and dosing are identical.
What is Fyavolv used for?
Fyavolv treats moderate-to-severe vasomotor symptoms of menopause (hot flashes, night sweats) and prevents postmenopausal osteoporosis in women at significant risk. It is prescribed only for women who still have a uterus, because the norethindrone protects the uterine lining.
What are the side effects of Fyavolv?
Most common in the first 4–6 weeks: breast tenderness, nausea, headache, bloating, and irregular vaginal bleeding or spotting. Less common but serious risks — blood clots, stroke, breast cancer with long-term use — are shared by all combined estrogen-plus-progestin oral therapies.
How do you take Fyavolv?
One tablet by mouth every day, at the same time each day. It is a continuous-combined regimen, so there are no scheduled hormone-free days. Spotting is common in the first 3–6 months and usually resolves as the endometrium adjusts.
Are there alternatives to Fyavolv?
Yes. Alternatives include Activella (estradiol + norethindrone), Prempro (conjugated equine estrogens + medroxyprogesterone), or a two-pill regimen of estradiol plus micronized progesterone (Prometrium). Women with elevated blood-clot or migraine risk may be better served by a transdermal patch (e.g., CombiPatch, Climara Pro). A Kindr clinician can help you choose.
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Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-06-19. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.