Hormone therapy — brand (combined)

CombiPatch

Estradiol + norethindrone patch

Twice-weekly combined estradiol-norethindrone patch — estrogen plus progestin in one patch.

Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-07-03

What it is

CombiPatch is a brand-name twice-weekly patch combining 17β-estradiol with norethindrone acetate (a synthetic progestin).

Available in 0.05/0.14 and 0.05/0.25 mg/day strengths.

How it works

Delivers estrogen plus progestin transdermally, bypassing the liver, with built-in endometrial protection.

Who it's for

Women with a uterus who want a single combined patch instead of patch + oral progesterone

Who should not take it

Estrogen-sensitive cancer history
Recent clot, stroke, or MI
Active liver disease

Common side effects

Patch-site irritation
Breast tenderness, headache, spotting early on

Evidence summary

FDA-approved for moderate-to-severe vasomotor symptoms in women with a uterus.
NAMS 2022: micronized progesterone is the preferred progestogen when available; norethindrone is an acceptable alternative.

Brand-name vs compounded

CombiPatch is an FDA-approved brand-name product. Many Kindr patients use compounded alternatives prepared by a state-licensed 503A pharmacy when a custom dose, custom combination, or different delivery form is clinically preferable. Both pathways are available through Kindr — your provider will recommend based on your individual needs.

Brand-name CombiPatch

FDA-approved finished product
Standardized doses
Available at most pharmacies
May be covered by insurance
Limited dose options

Compounded alternative

Custom dose for your needs
Prepared by FDA-registered 503A pharmacy
Not FDA-approved as a finished product
Typically cash pay
Flexible delivery forms

FAQ

Why pick CombiPatch over patch + Prometrium?

Single product, no nightly pill. Tradeoff: norethindrone is a synthetic progestin rather than bioidentical micronized progesterone.

Sources

Medically reviewed by Kindr Health Clinical Team
Kindr Health Inc. — Editorial & Clinical Team (physician-supervised)
NPI 1609792902 · Last reviewed: July 3, 2026

Other medications

Estradiol →

Hormone therapy

Micronized Progesterone →

Hormone therapy

Testosterone (low-dose, female-physiologic) →

Hormone therapy

Semaglutide →

GLP-1 weight care

This page is educational and is not a substitute for a clinical evaluation. Whether any medication is appropriate for you depends on your full medical history. Kindr providers make individualized prescribing decisions during a clinical visit.