Hormone therapy — brand (combined)

Climara Pro

Estradiol + levonorgestrel weekly patch

Once-weekly combined estradiol-levonorgestrel patch — estrogen plus progestin in one patch.

Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-07-03

What it is

Climara Pro is a brand-name once-weekly patch combining 17β-estradiol with levonorgestrel (a synthetic progestin).

0.045/0.015 mg/day.

How it works

Transdermal estrogen plus progestin delivered continuously over 7 days with built-in endometrial protection.

Who it's for

Women with a uterus who want once-weekly combined dosing

Who should not take it

Estrogen-sensitive cancer history
Recent clot, stroke, or MI
Active liver disease

Common side effects

Patch-site irritation
Breast tenderness, headache, spotting early on

Evidence summary

FDA-approved for moderate-to-severe vasomotor symptoms and osteoporosis prevention in women with a uterus.

Brand-name vs compounded

Climara Pro is an FDA-approved brand-name product. Many Kindr patients use compounded alternatives prepared by a state-licensed 503A pharmacy when a custom dose, custom combination, or different delivery form is clinically preferable. Both pathways are available through Kindr — your provider will recommend based on your individual needs.

Brand-name Climara Pro

FDA-approved finished product
Standardized doses
Available at most pharmacies
May be covered by insurance
Limited dose options

Compounded alternative

Custom dose for your needs
Prepared by FDA-registered 503A pharmacy
Not FDA-approved as a finished product
Typically cash pay
Flexible delivery forms

FAQ

How often do I change Climara Pro?

Once weekly.

Climara vs Climara Pro?

Climara is estrogen alone. Climara Pro adds levonorgestrel for women with a uterus.

Sources

Medically reviewed by Kindr Health Clinical Team
Kindr Health Inc. — Editorial & Clinical Team (physician-supervised)
NPI 1609792902 · Last reviewed: July 3, 2026

Other medications

Estradiol →

Hormone therapy

Micronized Progesterone →

Hormone therapy

Testosterone (low-dose, female-physiologic) →

Hormone therapy

Semaglutide →

GLP-1 weight care

This page is educational and is not a substitute for a clinical evaluation. Whether any medication is appropriate for you depends on your full medical history. Kindr providers make individualized prescribing decisions during a clinical visit.