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Targets the root drivers of menopause weight gain — blood sugar dysregulation and insulin resistance. The foundation everything else builds on.
70% of estrogen is metabolized in the gut. When the gut microbiome shifts in menopause — estrogen metabolism suffers. Gut Renew targets the estrobolome specifically.
Addresses the three hormonal drivers most responsible for menopause weight gain that estrogen replacement alone does not cover — cortisol, estrogen dominance, and thyroid function.
Muscle is your metabolic engine. Every pound lost accelerates metabolic decline. Muscle Guard supports lean muscle preservation and physical performance throughout the protocol.
The first two weeks prepare your metabolism for hormone optimization. Blood sugar regulation is addressed first — because insulin resistance is the primary driver of menopause-related weight gain and cannot be resolved with hormone therapy alone.
With metabolic priming underway, Phase 2 introduces hormone-specific support. DIM to manage estrogen metabolism, ashwagandha to lower cortisol, and thyroid support to maintain metabolic rate. Muscle Guard begins simultaneously — muscle loss starts from day one of hormonal decline.
The final phase is where the compounding effect is felt. Six weeks of metabolic priming, hormone support, gut repair, and muscle preservation creates a different hormonal and metabolic environment. Most women report noticeable changes in energy, body composition, and cognitive clarity by week eight.
Best for: Women just starting out or wanting to try Phase 1 before committing to the full protocol.
Start Phase 1 →Best for: Women who want data. Test your hormones before starting, run the protocol, retest at 90 days to measure the change.
Get Everything →Estrogen directly regulates insulin receptor sensitivity. As estrogen declines during menopause, insulin resistance increases — shifting fat storage from subcutaneous to visceral. This is why menopause weight gain concentrates in the abdomen, not the hips. MetaPrime targets this mechanism at the cellular level.
A specific community of gut bacteria — the estrobolome — produces an enzyme called beta-glucuronidase that determines how much estrogen is reactivated vs. excreted. Menopause disrupts this community. Gut Renew targets the estrobolome specifically with the Lactobacillus strains most studied for estrogen metabolism.
Muscle is metabolically active tissue. One pound of muscle burns approximately 6 calories per day at rest. Women lose 3-8% of muscle mass per decade after 30 — accelerating dramatically during menopause. The loss of muscle is the primary driver of metabolic rate decline — not fat gain itself. Muscle Guard targets this with the three compounds with the strongest evidence for muscle preservation.
Estrogen and cortisol have an inverse relationship. As estrogen declines, cortisol regulation weakens. Elevated cortisol drives visceral fat storage specifically — the dangerous abdominal fat associated with metabolic syndrome. Hormone Sync addresses cortisol directly with ashwagandha — the most studied adaptogen for cortisol reduction, with clinical data showing 28% reduction in cortisol levels.
Individual supplements address individual symptoms. MMR addresses the four interconnected drivers of menopause metabolic change simultaneously — insulin resistance, hormone imbalance, muscle loss, and gut disruption. Taking any one supplement misses the other three. The protocol works because it is sequenced and comprehensive, not because any single ingredient is miraculous.
Ninety days. Four formulas. The first protocol built specifically for what happens to metabolism during menopause.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 30-day money-back guarantee on first purchase.
Medically reviewed by Dr. Ana Lisa Carr, MD, MBA
Board-Certified Family Medicine Physician · Lead Provider / Medical Reviewer
NPI 1689841744 · Last reviewed: May 10, 2026