HRT · Progesterone
Micronized progesterone: uses, dosing, and why kindr uses bioidentical
Micronized progesterone (Prometrium) is the FDA-approved bioidentical progesterone used in modern HRT. It differs meaningfully from synthetic progestins like medroxyprogesterone in cardiovascular, breast, and mood profile.
What micronized progesterone actually does
- Endometrial protection against unopposed estrogen
- Sleep improvement via GABA-active metabolites
- Anxiety reduction and mood stabilization
- Modest hot flash reduction even without estrogen
- Breakthrough bleeding control in perimenopause
Standard uses
- Continuous combined HRT: 100 mg nightly
- Cyclic HRT: 200 mg nightly for 12-14 days per cycle
- Perimenopausal sleep/anxiety: 100-200 mg nightly
- Heavy bleeding: 200 mg days 14-28
Related
Prometrium dosage guide · progesterone for perimenopause · how HRT works.
Frequently asked questions
What is micronized progesterone?
Progesterone chemically identical to what the human body makes, milled to small particle size for oral absorption. Brand: Prometrium. Available as 100 mg and 200 mg capsules.
Does progesterone help with hot flashes?
Yes, modestly. Micronized progesterone alone (300 mg nightly) reduces vasomotor symptoms about 50-60% in postmenopausal women — smaller than estrogen but useful when estrogen is contraindicated.
Micronized progesterone vs progestins — what's the difference?
Synthetic progestins (medroxyprogesterone, norethindrone) increase breast cancer risk in combination HRT; micronized progesterone does not appear to. Progesterone also improves sleep and mood; progestins often do not.
How much micronized progesterone for perimenopause?
100-200 mg nightly is standard. See <a href="/prometrium-dosage">Prometrium dosage</a> for cyclic vs continuous regimens.
Is oral or vaginal progesterone better?
Oral produces the sleep-inducing allopregnanolone metabolite and is standard for HRT. Vaginal (200 mg) delivers similar endometrial protection with less sedation — useful if morning grogginess is a problem.
Considering a physician-supervised longevity protocol? Kindr Health evaluates peptide therapy as part of personalized perimenopause and menopause care.
Request your Longevity Consult →Related: FDA peptide review July 2026 briefing · Peptide therapy hub · Longevity service
Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-06-19. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.