HRT \u00b7 Delivery
Mirena IUD for HRT endometrial protection
Levonorgestrel IUD (Mirena) delivers progestin locally and provides excellent endometrial protection with minimal systemic absorption. Off-label in the US but standard practice in the UK for perimenopausal HRT.
Key points
- Levonorgestrel IUD
- Combine with any estrogen route
- Replace every 5–7 years
Frequently asked questions
Can I use Mirena for HRT?
Yes — well-established for endometrial protection in the UK and increasingly in the US.
How long does one IUD last?
5–7 years for HRT indication.
Does it stop periods?
Often — 70–80% amenorrhea by 12 months.
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Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-06-19. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.