Prometrium vs Provera
Prometrium is bioidentical progesterone. Provera is a synthetic progestin with different risk profile.
Breast cancer signal
Provera carried the WHI breast cancer signal. Micronized progesterone shows more favorable data.
Side effects
Prometrium is sedating (a feature at bedtime). Provera may worsen mood.
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Written and medically reviewed by the Kindr Health Clinical Team · Published 2026-06-19 · Last reviewed 2026-07-01. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.