Saliva vs blood hormone testing
Choose serum or dried blood spot for reliable estradiol monitoring.
Serum
Gold standard. Correlates with dose. Preferred for transdermal estradiol titration.
Saliva
Free-fraction only, high assay variability, not validated for pellet or oral HRT.
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Medically reviewed by Kindr Health Clinical Team · Last reviewed 2026-06-19. Compounded medications are prepared by FDA-registered 503A pharmacies and are not FDA-approved drug products.